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United States (Change Country)WAY-600 Chemical Structure
WAY-600 is a potent ATP-competitive mTOR inhibitor with an IC50 of about 9 nM. It is well reported that the mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. WAY-600 has significant selectivity against mTOR over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold). WAY-600 treated HEK293 cells indicated a 50% inhibition of polysomes by way-600 compared with the 11% suppression by rapamycin. Unlike the rapalogs,WAY-600 acutely blocked mTORC2-dependent phosphorylation of AKT in vitro and in vivo. In various cancer cells,WAY-600 inhibited the mTORC1 substrate P-S6K(T389) and mTORC2 substrate P-AKT(S473) at submicromolar concentrations without significant inhibition of P-AKT(T308). [1][2]
[1] Cancer Res 2009 Aug 1;69(15):6232-40
[2] Drug Discov Today Ther Strateg 2009;6(2):47-55
| Molecular Weight (WM): | 494.59 |
|---|---|
| Formula: | C28H30N8O |
| Solubility(R.T.:25°C): | DMSO 22mg/mL |
| Water <1mg/mL | |
| Ethanol 2mg/mL |
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