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Vascular Endothelial Growth Factor Receptor (VEGFR) is the receptor of VEGF. VEGFR is involved in cell proliferation, migration, survival and permeability. The VEGFs include five known structurally-related mammalian ligands (VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor, PLGF) and there are also three structurally related VEGFRs subtypes (VEGFR1, VEGFR2, and VEGFR3). [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1010 | BIBF1120 (Vargatef) | BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. |
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| S1264 | PD173074 | PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM. |
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| S1111 | Foretinib (GSK1363089, XL880) | XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively. |
(3)
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| S1018 | Dovitinib (TKI-258) | Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively. |
(3)
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| S1017 | Cediranib (AZD2171) | Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. |
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| S2161 | RAF265 (CHIR-265) | RAF265 (CHIR-265) is a selective and potent inhibitor of B-Raf and VEGFR2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively. |
(1)
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| S1207 | Tivozanib (AV-951) | AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively. |
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| S7082 | TAK-593 | TAK-593 is a novel dual VEGFR/PDGFR inhibitor. |
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| S2018 | ENMD-2076 L-(+)-Tartaric acid | ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively. |
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| S2859 | Golvatinib (E7050) | E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively. |
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| S2897 | ZM 306416 | ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively. |
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