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TW-37

Catalog No. S1121 5 5 3 Customer Review(s) Product Citations4 Product Citation(s)
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TW-37 Chemical Structure

Bio Information

TW-37 is a Bcl-2 protein family inhibitor with a Ki of 0.29 μM. TW-37 binds to the BH3 binding groove in Bcl-2 protein competing with BH3 peptides derived from Bid, Bim, and Bad proteins. TW-37 binds to Bcl-2 with a Ki value of 290 nM and also to Bcl-xL and Mcl-1 with high affinities. TW-37 potently inhibits cell growth in PC-3 prostate cancer cells with an IC50 value of 200 nM and effectively induces apoptosis in a dose-dependent manner. TW-37 has an IC50 of 1.1 μM for primary human endothelial cells and averaged 0.3 μM for head and neck cancer cells (OSCC3, UM-SCC-1, and UMSCC-74A). The combination of TW-37  and cisplatin showed enhanced cytotoxic effects for endothelial cells and HNSCC in vitro, compared with single agent treatment. [1][2]

References:

[1] Cancer Res 2006;66:8698-8706

[2] Mol Cancer Ther 2009;8:893-903

Chemical Information

Molecular Weight (WM): 573.7
Formula:

C33H35NO6S
Solubility(R.T.:25°C): DMSO 115mg/mL 
Water <1mg/mL 
Ethanol 4mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

Apoptosis >> Bcl-2 >> Bcl-2 Inhibitors

Recommended Screening Libraries

Related Inhibitors

Information  
ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.
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ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.
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Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
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HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM.
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AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.
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Related Antibodies

Information  
Reactivity: 薛亚红

TW-37 has been referenced in 4 publications.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.
Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis.
Extended survival of SH-SY5Y cells following overexpression of Lys67Glu neuroglobin is associated with stabilization of ΔψM.
Ligand binding, reactivity and biological activity of a distal pocket mutant of neuroglobin.

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Average Customer Review

(3 customer reviews)

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  • ;Cell Death Differ, 2012, 19(12), 1896-907
    TW-37 purchased from Selleck


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  • ;Dr. Christine Hawkins of La Trobe University
    TW-37 purchased from Selleck


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  • ;Dr. Zhang of Tianjin Medical University
    TW-37 purchased from Selleck

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;Cell Death Differ, 2012, 19(12), 1896-907


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;Dr. Christine Hawkins of La Trobe University

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