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TSU-68 (SU6668)

Catalog No. S1470 5 5 4 Customer Review(s) Product Citations2 Product Citation(s)
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TSU-68 (SU6668) Chemical Structure

Bio Information

TSU-68 (SU6668) has significant antitumor activity against many types of tumor xenograft explants in athymic mice. TSU-68 (SU6668) inhibits angiogenesis through several mechanisms, including the induction of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth. TSU-68 (SU6668) has the effect on blocking the tyrosine kinase phosphorylation of the receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies using in vivo experimental models of cancers such as colon cancer have reported that TSU-68 (SU6668) has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor angiogenesis. In vitro TSU-68 (SU6668) does not influence the proliferation of ovarian cancer cells. The administration of TSU-68 (SU6668) does not influence the concentration of VEGF or PDGF in the ascetic fluid of mice with peritoneal dissemination of ovarian cancer. TSU-68 (SU6668) does not act directly on VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [1][2]

References:

[1] Cancer Chemother Pharmacol 2011;67:1101–1109

[2] Int. J. Cancer 2005;114:224–229

Chemical Information

Molecular Weight (WM): 310.35
Formula:

C18H18N2O3
Solubility(R.T.:25°C): DMSO 62mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

Protein Tyrosine Kinase >> VEGFR >> VEGFR Inhibitors

Recommended Screening Libraries

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Information  
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Related Antibodies

Information  
Reactivity: 薛亚红

TSU-68 (SU6668) has been referenced in 2 publications.

Use of kinase inhibitors to correct ΔF508-CFTR function.
Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe (64)Cu-cyclam-RAFT-c(-RGDfK-) (4).

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Average Customer Review

(4 customer reviews)

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  • Data from [Angiogenesis 2012;ahead of print]
    TSU-68 (SU6668) purchased from Selleck


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  • Data from [Angiogenesis 2012;ahead of print]
    TSU-68 (SU6668) purchased from Selleck


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  • ;Molecular & Cellular Proteomics , 2012
    TSU-68 (SU6668) purchased from Selleck


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  • ;Molecular & Cellular Proteomics , 2012
    TSU-68 (SU6668) purchased from Selleck

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Data from [Angiogenesis 2012;ahead of print]


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Data from [Angiogenesis 2012;ahead of print]

+ See All 4 Customer Reviews of TSU-68 (SU6668)

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