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TNF-alpha, a tumor necrosis factor-alpha is a cytokine which triggers a signaling cascade. TNF-alpha can activate NF-kB by binding to the TNF receptors which can be divided into TNF-receptor1 and TNF-receptor2. TNF-alpha can also activate the signaling cascade of p38 MAPK, JNK and ERK. TNF-alpha can induce apoptosis by binding to TNF-receptor1, a death-domain-containing member of the TNFR super family.
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S8037 | Necrostatin-1 | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
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| S4902 | QNZ (EVP4593) | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
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