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As a founding member of the largest family of secreted morphogens in mammals, transforming growth factor β (TGF-β) can induce anchorage-independent growth. There are four subclasses of the TGF-β family with different biological functions. After transmembrane serine/threonine kinases binding form a heteromeric complex of type I and II receptors, TGF-β signaling pathway is activated. Smad signaling pathway is activated after the phosphorylation of the type I receptor by the type II kinase. In the eponymous TGF-β pathway, this occurs via ligand-induced cooperative assembly of the receptor complex. There are so many important targets related to Smad including HDAC1, Notch, STAT3, ERK and p38. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S1067 | SB 431542 | SB 431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM. |
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| S2230 | LY2157299 | LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. |
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| S2618 | LDN193189 | LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. |
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| S2704 | LY2109761 | LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively. |
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| S1476 | SB 525334 | SB 525334 is a potent and selective inhibitor of TGF-β1 (ALK5) with IC50 of 14.3 nM. |
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| S2907 | Pirfenidone | Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. |
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| S2186 | SB-505124 | SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively. |
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| S2750 | GW788388 | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM. |
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| S2805 | LY364947 | LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM. |
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