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Telatinib (BAY 57-9352)

Catalog No. S2231

Telatinib (BAY 57-9352) Chemical Structure

Bio Information

Telatinib (BAY 57-9352) is an orally available, potent multitargeted VEGFR-2, VEGFR-3, PDGFR-β and c-Kit tyrosine kinases inhibitor with an IC50 of 19 nM for the inhibition of VEGFR-2 autophosphorylation. Telatinib (BAY 57-9352, CP 127374; KOS 953; NSC 330507; Tanespimycin) also inhibits VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVECs) with an IC50 of 26 nM and PDGF-stimulated growth of human aortic smooth muscle cells with an IC50 of 249 nM. Telatinib (BAY 57-9352, CP 127374; KOS 953; NSC 330507; Tanespimycin) demonstrates anti-tumor activity in various cancer models. Formation of the N-glucuronides of telatinib is identiﬁed as the major biotransformation pathway in man. Telatinib (BAY 57-9352, CP 127374; KOS 953; NSC 330507; Tanespimycin) is metabolized by various CYP isoforms and UGT1A4. ^[1][2][3]

References:

[1] Clin Cancer Res 2008;14:3470-3476

[2] J Clin Oncol 2009;27:4169-4176

[3] British Journal of Cancer 2008;99:1579 – 1585

Chemical Information

Molecular Weight (WM):	409.83
Formula:	C₂₀H₁₆ClN₅O₃

Solubility(R.T.:25°C):	DMSO 82mg/mL
	Water <1mg/mL
	Ethanol 1mg/mL

Quality Control

View current batch:

Purity= 99.02% Purity= 97.58% Purity= 97.64% H-NMR HPLC

Research Area

Protein Tyrosine Kinase >> VEGFR >> VEGFR Inhibitors

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Related Antibodies

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Reactivity: 薛亚红

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