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Syk, a non-receptor protein tyrosine kinase, is a key mediator of immune receptor signaling and platelets. Syk, with Src homology 2 (SH2) domains, plays essential roles in signalling activated by various types of receptors such as FccR, CR3, Dectin-1 and apoptotic cell-recognizing receptor. Syk also plays an important part in the uncontrolled growth of tumor cells. The tandem SH2-domain-containing Syk is activated when classical ITAMs is tyrosine-phosphorylated by SRC kinases. The downstream of syk includes Ras, Raf and MAPK signaling pathway.
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S2194 | R406 | R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3. |
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| S1533 | R406(free base) | R406 (free base) is a Syk inhibitor with IC50 of 41 nM. |
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| S2206 | R935788 (Fostamatinib disodium, R788 disodium) | R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM. |
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| S3026 | Piceatannol | Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM. |
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| S2625 | R788 (Fostamatinib) | R788 (Fostamatinib) is a Syk inhibitor with IC50 of 41 nM. |
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