Syk, a non-receptor protein tyrosine kinase, is a key mediator of immune receptor signaling and platelets. Syk, with Src homology 2 (SH2) domains, plays essential roles in signalling activated by various types of receptors such as FccR, CR3, Dectin-1 and apoptotic cell-recognizing receptor. Syk also plays an important part in the uncontrolled growth of tumor cells. The tandem SH2-domain-containing Syk is activated when classical ITAMs is tyrosine-phosphorylated by SRC kinases. The downstream of syk includes Ras, Raf and MAPK signaling pathway.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S2194||R406||R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.||(1)||(1)|
|S1533||R406(free base)||R406 (free base) is a Syk inhibitor with IC50 of 41 nM.||(1)||(1)|
|S2206||R935788 (Fostamatinib disodium, R788 disodium)||R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.|
|S3026||Piceatannol||Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM.|
|S2625||R788 (Fostamatinib)||R788 (Fostamatinib) is a Syk inhibitor with IC50 of 41 nM.|