Smoothened (smo), a G protein-coupled receptor, drives the Hedgehog signalling pathway and is involved in gene expression and Gli family transcription factors. The core members of the Smo signalling pathway include the ligand (Hedgehog, Hh), the receptor (Patched, Ptc), several transducers such as Smoothened (Smo) and the ytoplasmic complex formed by the kinesin-like protein Costal-2 (Cos2), the serine/threonine kinase Fused (Fu), the novel protein Suppressor of fused [Su(fu)], and the transcription factor Cubitus interruptus (Ci). SMO is classified as a proto-oncogene because the tumour suppressor PTCH represses signalling by SMO, and SHH relieves this repression.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S2151||LDE225 (NVP-LDE225,Erismodegib)||LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.||(1)|
|S1146||Cyclopamine||Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.||(4)||(4)|
|S2157||LY2940680||LY2940680 binds to the Smo receptor and potently inhibits Hh signaling.|
|S2777||PF-5274857||PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively.|
|S7092||SANT-1||SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.|
|S3042||Purmorphamine||Purmorphamine directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with Smo antagonist and also is a inducer of osteoblast differentiation with EC50 of 1μM.|