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RNA interference (RNAi) is a gene-silencing process that targets mRNA hence lowering protein expression. The key RNAi substrates regulating this process are shRNA, miRNA and siRNA. While miRNAs are naturally occurring non-coding small RNAs, which plays important role in gene-expression regulation, gene-specific shRNAs and siRNAs are powerful tools to effectively knockdown target gene expression.
We offer siRNA silencers targeted to all known human gene. If you can not find the target siRNA of interest on the product list, please send your request to [email protected] .Our siRNA Kit includes:3 unique siRNA duplexes,Negative Control siRNA,Positive Control siRNA for beta-actin,and Primer.Selleck guarantees that at least one of the three duplexes in the kit provide 70% or greater knockdown of the target mRNA.
Selleck siRNA Libraries will enable rapid, low-cost, high-throughput functional deficiency research, screening important genes, including Kinase, Phosphatase, JAK/ATAT, and other important signal pathways.
when the fluorescent transfection control duplex indicates that >80% of the cells have been transfected and the positive control provides 80% knockdown efficiency.For non-conforming siRNA, requests for replacement must be made within ninety (90) days from the date of delivery of the siRNA kit. We will design and prepare another two pair of siRNA for free. To arrange a free replacement, please contact our technical support team at [email protected]. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
