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Roscovitine (Seliciclib, CYC202)

Catalog No. S1153 5 5 4 Customer Review(s) Product Citations3 Product Citation(s)
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Roscovitine (Seliciclib, CYC202) Chemical Structure

Bio Information

Roscovitine (Seliciclib, CYC202) is a potent and selective inhibitor of cyclin-dependent kinases (cdks). This agent displays higher inhibitory potency and higher selectivity compared to olomoucine. [1]
Roscovitine (Seliciclib, CYC202) inhibits p34 cdc2/cyclin B (IC50 = 0.65 µM), p33 cdk2/cyclin A(IC50 = 0.70 µM), p33 cdk2/cyclin E (IC50 = 0.70 µM), and p33 cdk2/p35(IC50 = 0.20 µM) by competing for the ATP binding domain of these kinases.  Roscovitine (Seliciclib, CYC202) exhibits very low sensitivity towards related kinases, such as erk1 and erk2 (IC50 = 34 µM and 14 µM, respectively) .[2]
Roscovitine (Seliciclib, CYC202) doesnot significantly affect the activity of other protein kinases even at 100 µM and compared to olomoucine. Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. [3]

References:

[3] Anticancer Res. 1998 Mar-Apr;18(2A):751-5.

[1] Eur. J. Biochem 1997;243：518-526

[2] The Plant Journal 1997;12(1), 191-202

Chemical Information

Molecular Weight (WM): 354.45
Formula:

C19H26N6O
Solubility(R.T.:25°C): DMSO 71mg/mL 
Water <1mg/mL 
Ethanol 6mg/mL 

Quality Control

View current batch:
H-NMR HPLC H-NMR HPLC H-NMR HPLC

Research Area

Cell Cycle >> CDK >> CDK Inhibitors

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Related Antibodies

Information  
Reactivity: 薛亚红

Roscovitine (Seliciclib, CYC202) has been referenced in 3 publications.

Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor.
Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization.
The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer.

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Average Customer Review

(4 customer reviews)

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  • Data from [PNAS 2011;108, 8417]
    Roscovitine (Seliciclib, CYC202)  purchased from Selleck


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  • ;Bai Bo University of Hong Kong
    Roscovitine (Seliciclib, CYC202)  purchased from Selleck


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  • ;The Journal of Neuroscience, 2012, 32(32):11050-11066
    Roscovitine (Seliciclib, CYC202)  purchased from Selleck


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  • Data from [PNAS 2011;108, 8417]
    Roscovitine (Seliciclib, CYC202)  purchased from Selleck

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Data from [PNAS 2011;108, 8417]


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;Bai Bo University of Hong Kong

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