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B-raf plays crucial roles in MAPK signaling pathway, ErbB signaling pathway, Insulin signaling pathway and mTOR signaling pathway which have effect on cell survival, growth and differentiation. RAF can be regulated by RAS and PKC. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1152 | PLX-4720 | PLX-4720 is a potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively. |
 (17)
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| S2807 | Dabrafenib (GSK2118436) | Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively. |
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| S1104 | GDC-0879 | GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM. |
(6)
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| S2161 | RAF265 (CHIR-265) | RAF265 (CHIR-265) is a selective and potent inhibitor of B-Raf and VEGFR2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively. |
(1)
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| S2746 | AZ628 | AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively. |
(1)
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| S2720 | ZM 336372 | ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM. |
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| S2220 | SB590885 | SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM. |
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| S7001 | PF-04880594 | PF-04880594 is a RAF inhibitor for BRAF and c-RAF with IC50 of 0.19 nM and 0.39 nM, respectively. |
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| S2872 | GW5074 | GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM. |
(1)
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| S8015 | CEP-32496 | CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively. |
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| S2202 | NVP-BHG712 | NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively. |
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