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Raf Inhibitors

Cat.No. Product Name Information Publication Customer Review
S1152 PLX-4720 PLX-4720 is a potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively. (17)
S2807 Dabrafenib (GSK2118436) Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively.
S1104 GDC-0879 GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM. (6)
S2161 RAF265 (CHIR-265) RAF265 (CHIR-265) is a selective and potent inhibitor of B-Raf and VEGFR2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively. (1)
S2746 AZ628 AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively. (1)
S2720 ZM 336372 ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM.
S2220 SB590885 SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM.
S7121 MLN2480 MLN-2480 (BIIB-024) is a pan-Raf inhibitor.
S7001 PF-04880594 PF-04880594 is a RAF inhibitor for BRAF and c-RAF with IC50 of 0.19 nM and 0.39 nM, respectively.
S2872 GW5074 GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM. (1)
S8015 CEP-32496 CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively.
S2202 NVP-BHG712 NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively.
S2200 Raf265 derivative Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM.