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R406

Catalog No. S2194 1 Customer Review(s)

Product Citations

1 Product Citation(s)

R406 Chemical Structure

Bio Information

R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 has shown efficacy in a number of animal models of immune disorders. R406 inhibited airway hyperresponsiveness (AHR) and airway inflammation in mice, at least in part through alteration of mast cell and dendritic cell functions. Similarly, R406 treatment ameliorated joint inflammation in a number of rodent models of rheumatoid arthritis and also blocked JNK-mediated gene expression in human synoviocytes, suggesting a possible role in the treatment of rheumatoid arthritis. ^[1][2]

References:

[1] Toxicology and Applied Pharmacology 2007;221:268–277

[2] Xenobiotica. 2010 Jun;40(6):415-23.

Chemical Information

Molecular Weight (WM):	628.63
Formula:	C₂₂H₂₃FN₆O₅.C₆H₆O₃S

Solubility(R.T.:25°C):	DMSO 126mg/mL
	Water <1mg/mL
	Ethanol 8mg/mL

Quality Control

View current batch:

Purity= 99.11% H-NMR HPLC Purity= 99.05% H-NMR HPLC Purity= 99.07% H-NMR HPLC

Research Area

Angiogenesis >> Syk >> Syk Inhibitors

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Related Antibodies

Product Name	Information

Reactivity: 薛亚红

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Average Customer Review

(1 customer reviews)

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;Clin Cancer Res, 2013, 19(3), 586-597
R406 purchased from Selleck

Quality Matters

This product has been referenced in

[Clin Cancer Res 2012;ahead of print]

+ See All 1 Product Citations of R406

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;Clin Cancer Res, 2013, 19(3), 586-597

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