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Trichostatin A (TSA)

Catalog No. S1045 5 5 1 Customer Review(s) Product Citations1 Product Citation(s)
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Trichostatin A (TSA) Chemical Structure

Bio Information

An antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture. TSA inhibited proliferation of eight breast carcinoma cell lines with mean ± SD IC50 of 124.4 ± 120.4 nm (range, 26.4–308.1 nm). HDAC inhibitory activity of TSA was similar in all cell lines with mean ± SD IC50 of 2.4 ± 0.5 nm (range, 1.5–2.9 nm), and TSA treatment resulted in pronouncing histone H4 hyperacetylation. [1]

References:

[1] Clin Cancer Res 2001;7:971-976

Chemical Information

Molecular Weight (WM): 302.4
Formula:

C17H22N2O3
Solubility(R.T.:25°C): DMSO 23mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Quality Control

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H-NMR HPLC H-NMR HPLC H-NMR HPLC

Research Area

Epigenetics >> HDAC >> HDAC Inhibitors

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Related Antibodies

Information  
Reactivity: 薛亚红

Trichostatin A (TSA) has been referenced in 1 publications.

Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells.

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(1 customer reviews)

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  • ;Dr. Zhang of Tianjin Medical University
    Trichostatin A (TSA) purchased from Selleck

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;Dr. Zhang of Tianjin Medical University

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