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United States (Change Country)Motesanib Diphosphate (AMG-706) Chemical Structure
Motesanib (AMG-706) is an orally bioavailable diphosphate salt of a multiple receptor tyrosine kinase inhibitor with potential antineoplastic activity[1]. This reagent selectively targets and inhibits VEGFR1/2/3(IC50: 2 nM /3 nM /6 nM), PDGFR (84nM), kit (8nM), and Ret (59nM)receptors, thereby inhibiting angiogenesis and cellular proliferation. Oral administration of AMG 706 potently inhibited VEGF-induced angiogenesis in the rat corneal model and induced regression of established A431 xenografts [1] .This compound also performed antitumor activity in breast cancer xenografts and was currently being studied in clinical trials for the treatment of thyroid cancer and other advanced solid tumors[2,3,4]
[1] Cancer Res 2006;66:8715-8721
[2] Clin Cancer Res 2009;15:110-118
[3] N Engl J Med 2008;359:31-42
[4] J Clin Oncol 2007;25:2369-2376.
| Molecular Weight (WM): | 569.44 |
|---|---|
| Formula: | C22H23N5O.2H3PO4 |
| Solubility(R.T.:25°C): | DMSO 114mg/mL |
| Water 114mg/mL | |
| Ethanol <1mg/mL |
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;Cardiovasc Res Motesanib Diphosphate (AMG-706) purchased from Selleck
;Cardiovasc Res, 2011, 91(3), 402-411 Motesanib Diphosphate (AMG-706) purchased from Selleck
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