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United States (Change Country)BS-181 HCl Chemical Structure
BS-181 HCl is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase. Testing of other CDKs as well as another 69 kinases showed that BS-181 HCl only inhibited CDK2 at concentrations lower than 1 μM, with CDK2 being inhibited 35-fold less potently (IC50 880 nM) than CDK7. In MCF-7 cells, BS-181 HCl inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines, and showed antitumor effects in vivo. [1]
[1] Cancer Res 2009 August 1;69(15): 6208–6215
| Molecular Weight (WM): | 416.99 |
|---|---|
| Formula: | C22H32N6.HCl |
| Solubility(R.T.:25°C): | DMSO 83mg/mL |
| Water 3mg/mL | |
| Ethanol 27mg/mL |
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;Dr. Vladimir Krystof of Palacky University BS-181 HCl purchased from Selleck
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