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BIRB 796 (Doramapimod)

Catalog No. S1574 5 5 1 Customer Review(s) Product Citations5 Product Citation(s)
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BIRB 796 (Doramapimod) Chemical Structure

Bio Information

BIRB 796 (Doramapimod) is a small molecule p38 MAPK inhibitor with an Kd of 0.1 nM.
It is more potent than SB 203580 on p38α and p38β MAPKs; It is a potential agent for the treatment of inflammatory diseases. [1] BIRB 796, alone and in combination with conventional and novel therapeutic agents. BIRB 796 blocked baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation, thereby enhancing cytotoxicity and caspase activation. [2]

References:

[1] Bioorganic & Medicinal Chemistry Letters 2003;13:3101–3104

[2] British Journal of Haematology 2006;136:414–423

Chemical Information

Molecular Weight (WM): 527.66
Formula:

C31H37N5O3
Solubility(R.T.:25°C): DMSO 106mg/mL 
Water <1mg/mL 
Ethanol 106mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

MAPK >> p38 MAPK >> p38 MAPK Inhibitors

Recommended Screening Libraries

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Information  
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Related Antibodies

Information  
Reactivity: 薛亚红

BIRB 796 (Doramapimod) has been referenced in 5 publications.

RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway.
Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.
BIRB796, the Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances the Efficacy of Chemotherapeutic Agents in ABCB1 Overexpression Cells.
p38 Mitogen-activated protein kinase and extracellular signal regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47(phox) activation in neutrophils.

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