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United States (Change Country)BI6727 (Volasertib) Chemical Structure
BI 6727 is a highly potent Polo-like kinase inhibitor with an IC50 of 0 .87 nM BI 6727 has an EC50 of 11-37 nM on a panel of cancer cell lines and selective dihydropteridinone with distinct properties. BI 6727 has a pharmacokinetic profile favoring sustained exposure of tumor tissues with a high volume of distribution and a long terminal half-life in mice. BI 6727 has physicochemical and pharmacokinetic properties that allow in vivo testing of i.v. as well as oral formulations, adding flexibility to dosing schedules. BI 6727 shows marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer. [1][2][3]
[1] Clin Cancer Res 2009;15:3094-3102
[2] The Oncologist 2009;14:559–570
[3] Cancer Res 2011;71:1385-1395
| Molecular Weight (WM): | 618.81 |
|---|---|
| Formula: | C34H50N8O3 |
| Solubility(R.T.:25°C): | DMSO 50mg/mL |
| Water <1mg/mL | |
| Ethanol 124mg/mL |
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;Dr. Xiangbing Meng from University of Iowa BI6727 (Volasertib) purchased from Selleck
Data independently produced by ;Dr. Xiangbing Meng from University of Iowa BI6727 (Volasertib) purchased from Selleck
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