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AG-490 Chemical Structure
AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8μM for EGFR and JAK, respectively. It inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. It selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. It inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. It displays apoptotic and antiproliferative properties with IC50 of 1.7, 2.8 and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively. [1][2]
[1] J Immunol 1999;162;3897-3904
[2] Nature 1996;379:645-648
| Molecular Weight (WM): | 294.30 |
|---|---|
| Formula: | C17H14N2O3 |
| Solubility(R.T.:25°C): | DMSO 59mg/mL |
| Water <1mg/mL | |
| Ethanol 6mg/mL |
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