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Linifanib (ABT-869)

Catalog No. S1003 3 Customer Review(s)

Product Citations

2 Product Citation(s)

Linifanib (ABT-869) Chemical Structure

Bio Information

Linifanib (ABT-869) is a structurally novel, potent RTK and VEGF and PDGF receptor families inhibitor with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. It has much less activity (IC50s > 1 μM) against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. In vivo ABT-869 is effective orally in the mechanism-based murine models of VEGF-induced uterine edema (ED50 = 0.5 mg/kg) and corneal angiogenesis ( >50%inhibition, 15 mg/kg ). ^[1][2]

References:

[1] Mol Cancer Ther 2006;5:995-1006

[2] Mol Cancer Ther 2006;5:1007-1013

Chemical Information

Molecular Weight (WM):	375.41
Formula:	C₂₁H₁₈FN₅O

Solubility(R.T.:25°C):	DMSO 75mg/mL
	Water <1mg/mL
	Ethanol <1mg/mL

Quality Control

View current batch:

Purity= 99.51% H-NMR HPLC Purity= 99.61% Purity= 99.05% H-NMR HPLC

Research Area

Protein Tyrosine Kinase >> VEGFR >> VEGFR Inhibitors

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Related Inhibitors

Product Name	Information

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

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BIBF1120 (Vargatef)

BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

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Cediranib (AZD2171)

Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

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Dovitinib (TKI-258)

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

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Imatinib Mesylate

Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

100mg
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Related Antibodies

Product Name	Information

Reactivity: 薛亚红

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Average Customer Review

(3 customer reviews)

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;J Pharmacol Exp Ther, 2012, 343(3), 617-27
Linifanib (ABT-869) purchased from Selleck

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Data from [Liver Int 2011;32(3), 400-409]
Linifanib (ABT-869) purchased from Selleck

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;Dr. Zhang of Tianjin Medical University
Linifanib (ABT-869) purchased from Selleck

Quality Matters

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Check our customer reviews

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;J Pharmacol Exp Ther, 2012, 343(3), 617-27

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Data from [Liver Int 2011;32(3), 400-409]

+ See All 3 Customer Reviews of Linifanib (ABT-869)

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