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PP-121

Catalog No. S2622 1 Customer Review(s)

PP-121 Chemical Structure

Bio Information

PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 μM for p110α, p110β, p110δ, p110γ, DNA-PK, mTOR and PDGFR, respectively. PP121 also inhibits Abl, Hck, Src,Src(T338I), VEGFR2, EGFR EphB4 with IC50 of 0.018, 0.008, 0.014, 0.22, 0.012, 0.26, 0.19 μM, respectively. PP121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP121 blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor. PP121 achieves its dual potency by targeting a residue (Glu310 in Src) that has been structurally conserved between kinase families. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. ^[1]

References:

[1] Nat Chem Biol. 2008;4(11): 691–699

Chemical Information

Molecular Weight (WM):	319.36
Formula:	C₁₇H₁₇N₇

Solubility(R.T.:25°C):	DMSO 64mg/mL
	Water <1mg/mL
	Ethanol 2mg/mL

Quality Control

View current batch:

Purity= 99.21% H-NMR HPLC

Research Area

Protein Tyrosine Kinase >> PDGFR >> PDGFR Inhibitors

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Related Antibodies

Product Name	Information

Reactivity: 薛亚红

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;Dr. Zhang of Tianjin Medical University
PP-121 purchased from Selleck

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