Pim

The PIM family kinases,which is belong to serine/threonine kinase, consist of 3 members which are PIM-1, PIM-2, and PIM-3. Pim-1 substrate include nuclear adapter protein p100, which is an activator of the c-Myb transcription factor, and transcription factor NFATc, which is involved in relaying signals from the T-cell receptor.Pim-1 in preventing cell death since the inactivation of Bad can enhance Bcl-2 activity and thereby promotes cell survival. Pim-1 binds and phosphorylates the phosphatase Cdc25A, which is a positive G1-specific cell cycle regulator. Two other Pim-1 substrates, SOCS1 and SOCS3 also belong to the group of adapter proteins and are involved in the negative regulation of STATs or TNF-receptor signal transduction pathways.