The PIM family kinases,which is belong to serine/threonine kinase, consist of 3 members which are PIM-1, PIM-2, and PIM-3. Pim-1 substrate include nuclear adapter protein p100, which is an activator of the c-Myb transcription factor, and transcription factor NFATc, which is involved in relaying signals from the T-cell receptor.Pim-1 in preventing cell death since the inactivation of Bad can enhance Bcl-2 activity and thereby promotes cell survival. Pim-1 binds and phosphorylates the phosphatase Cdc25A, which is a positive G1-specific cell cycle regulator. Two other Pim-1 substrates, SOCS1 and SOCS3 also belong to the group of adapter proteins and are involved in the negative regulation of STATs or TNF-receptor signal transduction pathways.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S2198||SGI-1776 free base||SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively.||(5)||(1)|
|S8005||SMI-4a||SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM.|