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Phosphatidylinositol 3-kinase (PI 3-kinase or PI3K) is a famous target which is the upstream of akt because PI3K can activate Akt when PI3K is activated by growth factors including EGF, IGF, TGF-α and so on. The activation Class IA PI3Ks by growth factors is receptor tyrosine kinase (RTK)-dependent activation. Class IB PI3K is primarily regulated by small G-proteins such as Ras. PI3K is a key enzyme involved in cell processes, apoptosis and cancer. PI3K with mTOR, akt and MEK plays a key role in cancer. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1009 | BEZ235 (NVP-BEZ235) | BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
 (25)
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| S1105 | LY294002 | LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, respectively. |
(11)
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(3)
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| S1065 | GDC-0941 | GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. |
(24)
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(4)
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| S2226 | CAL-101 (GS-1101) | CAL-101 is a selective PI3K class I inhibitor of p110δ with IC50 of 2.5 nM. |
(4)
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(1)
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| S2247 | BKM120 (NVP-BKM120) | BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively. |
(1)
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(2)
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| S2638 | NU7441 (KU-57788) | NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM. |
(1)
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(1)
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| S2814 | BYL719 | BYL719 strongly and selectively inhibits PI3Kα. |
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| S7028 | IPI-145 (INK1197) | IPI-145 (INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM. |
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| S8002 | GSK2636771 | GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor. |
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| S2870 | TG 100713 | TG 100713 is a PI3K inhibitor for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. |
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| S2759 | PI3K/HDAC InhibitorⅠ | PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively. |
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