Microbiology is related to different virus. We choose different targets to resist virus. Hsp90, Hsp70 and CCR5 are all targets about HIV. Integrase which is a novel target for antiretroviral therapy enables retrovirus genetic material to be integrated into the host chromosome. It is essential to retrovirus replication. Procollagen C-proteinase is a target which is derived from morphogenetic protein 1 (BMP-1). HCV protease is obviously related to HCV.