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PD173074

Catalog No. S1264 5 5 2 Customer Review(s) Product Citations5 Product Citation(s)
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PD173074 Chemical Structure

Bio Information

PD173074 is a potent ATP-competitive, reversible FGFR and VEGFR inhibitor with IC50 of 5, 21.5 and ~100 nM for FGFR3, FGFR1 and VEGFR2, respectively.PD173074 is a cell-permeable pyridopyrimidine compound. PD 173074 arrests the G0/G1 phase of FGFR3-expressing cells. PD173074 inhibits PDGFR and c-Src only at much higher concentration (IC50 = 17.6 µM, 19.8 µM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 µM. Shown to inhibit the autophosphorylation of endogenous FGFR1 (IC50 <5 nM) and overexpressed VEGFR2 (IC50 <200 nM) in NIH3T3 cells in vitro, and FGF- and VEGF-induced angiogenesis in mice in vivo. [1][2]

References:

[1] Cancer Res 2008;68:6902-6907

[2] Journal of Neuroscience Research 2003;74:486–493

Chemical Information

Molecular Weight (WM): 523.67
Formula:

C28H41N7O3
Solubility(R.T.:25°C): DMSO 105mg/mL 
Water <1mg/mL 
Ethanol 105mg/mL 

Quality Control

View current batch:
H-NMR HPLC H-NMR HPLC H-NMR HPLC

Research Area

Angiogenesis >> FGFR >> FGFR Inhibitors

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Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
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Related Antibodies

Information  
Reactivity: 薛亚红

PD173074 has been referenced in 5 publications.

The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2.
Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium.
Use of kinase inhibitors to correct ΔF508-CFTR function.
Aquaporin3 Is Required for FGF-2-Induced Migration of Human Breast Cancers.
L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.

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Average Customer Review

(2 customer reviews)

  • Click to enlarge

  • Data from [SCIENCE 2011;331, 912-916]
    PD173074 purchased from Selleck


  • Click to enlarge

  • ;Molecular & Cellular Proteomics , 2012
    PD173074 purchased from Selleck

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Click to enlarge

Data from [SCIENCE 2011;331, 912-916]


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;Molecular & Cellular Proteomics , 2012

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