p53 is a tumor suppressor protein which plays a critical role in apoptosis, Cell-cycle arrest, and DNA damage. p53 give a contribution to apoptosis with BAK, BAX and BCL-2. p53 can be phosphorylated by ATM / ATR / DNA-PK, Chk1 / Chk2, MAPK (JNK1-3, ERK1-2, p38 MAPK) and some other kinases. Cell-cycle arrest, DNA repair, Angiogenesis are related to p53 because CDKN1A, 14-3-3-σ and MMP2 are all p53-target gene which can be regulated by p53. A protein called Mdm2 which keep a continuous degradation of p53 binds to p53 to prevent p53 from transporting from nucleus to the cytosol.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S1172||JNJ 26854165 (Serdemetan)||JNJ 26854165 (Serdemetan) is an orally bioavailable HDM2 antagonist.|
|S2678||NSC-207895 (XI-006)||NSC-207895 suppresses MDMX with IC50 of 2.5 µM, leading to enhanced p53 stabilization/activation and DNA damage.|
|S2781||RITA (NSC 652287)||RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells.|
|S2929||Pifithrin-α||Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.|
|S8000||Tenovin-1||Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.|