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p38 mapks (P38 mitogen-activated protein kinases) which include p38 isoforms α, β, γ, and δ are a member of mitogen-activated protein kinases family. p38 mapk can be activated by LPS, proinflammatory cytokines, various environmental stresses. p38 MAPK phosphorylates various substrates including MAPK-activated protein kinase 2 (MAPKAPK2). p38 MAPK which is activated in the human brain with Alzheimer’s disease plays more than one role in Alzheimer's disease (AD).
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S1076 | SB 203580 | SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM. |
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| S1574 | BIRB 796 (Doramapimod) | BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM. |
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| S1077 | SB 202190 | SB 202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α and p38β with IC50 of 50 nM and 100 nM, respectively. |
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| S1494 | LY2228820 | LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM. |
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| S6005 | VX-702 | VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM. |
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| S2726 | PH-797804 | PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM. |
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| S1458 | VX-745 | VX-745 is a potent and selective inhibitor of p38α MAPK and p38β MAPK with IC50 of 10 nM and 220 nM, respectively. |
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| S2928 | TAK 715 | TAK 715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM. |
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