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NVP-BEP800

Catalog No. S1498 4.5 5 2 Customer Review(s) Product Citations2 Product Citation(s)
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NVP-BEP800 Chemical Structure

Bio Information

NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor with an IC50 of 0.058 ± 0.006 μM. It binds to the NH2-terminal ATP-binding pocket of Hsp90. Given the mechanism of action, preclinical activity profile, tolerability, and pharmaceutical properties, NVP-BEP800 is an exciting new oral Hsp90 inhibitor warranting further development. [1][2]

References:

[1] Mol Cancer Ther 2010;9:906-919

[2] British Journal of Haematology 2009;147:319–327

Chemical Information

Molecular Weight (WM): 480.41
Formula:

C21H23Cl2N5O2S
Solubility(R.T.:25°C): DMSO <1mg/mL 
Water <1mg/mL 
Ethanol 15mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

Cytoskeletal Signaling >> HSP (e.g. HSP90) >> HSP (e.g. HSP90) Inhibitors

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Related Antibodies

Information  
Reactivity: 薛亚红

NVP-BEP800 has been referenced in 2 publications.

Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

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Average Customer Review

(2 customer reviews)

  • Click to enlarge

  • Data from [Cancer Cell 2011;20, 400-13]
    NVP-BEP800 purchased from Selleck


  • Click to enlarge

  • ;Dr Swee Sharp and Professor Paul Workman from Cancer Research UK
    NVP-BEP800 purchased from Selleck

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Click to enlarge

Data from [Cancer Cell 2011;20, 400-13]


Click to enlarge

;Dr Swee Sharp and Professor Paul Workman from Cancer Research UK

Your Recent History

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