- |
My Account- |
United States (Change Country)
1 Product Citation(s)
Mubritinib (TAK 165) Chemical Structure
Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5.Mubritinib(TAK 165) displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Mubritinib(TAK 165) exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. [1][2]
[2] J. Med. Chem. 1997;40: 408-412
| Molecular Weight (WM): | 468.47 |
|---|---|
| Formula: | C25H23F3N4O2 |
| Solubility(R.T.:25°C): | DMSO 13mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL |
A collection of 715 inhibitors
A collection of 271 kinase inhibitors
A collection of 785 FDA approved drugs
A collection of 144 natural products
A collection of 84 chemotherapeutic agents
A collection of 1463 bioactive compounds
A collection of 117 tyrosine kinase inhibitors
Keywords:buy Mubritinib (TAK 165) | Mubritinib (TAK 165) supplier | purchase Mubritinib (TAK 165) | Mubritinib (TAK 165) cost | Mubritinib (TAK 165) manufacturer | order Mubritinib (TAK 165) | Mubritinib (TAK 165) distributor
