mTOR Inhibition | mTOR Inhibitor Review

Research Area

Cat.No.	Product Name	Information	Publication	Customer Review
S1009	BEZ235 (NVP-BEZ235)	BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.	(25)	(7)
S1555	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR with IC50 of 0.8 nM.	(5)	(2)
S1038	PI-103	PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.	(5)	(4)
S2811	INK 128 (MLN0128)	INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM.
S2218	PP242	PP242 is a selective mTOR inhibitor with IC50 of 8 nM.	(1)	(1)
S2827	Torin 1	Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
S1022	Deforolimus (Ridaforolimus)	Deforolimus (Ridaforolimus, AP23573, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM.	(1)	(1)
S8040	GDC-0349
S2817	Torin 2	Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.
S2783	AZD2014	AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.
S2749	NVP-BGT226	NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM.