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MLN8054

Catalog No. S1100 5 5 3 Customer Review(s) Product Citations3 Product Citation(s)
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MLN8054 Chemical Structure

Bio Information

MLN8054 is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity[1] .
MLN8054 inhibits recombinant Aurora A kinase activity in vitro and is selective for Aurora A (IC50 = 0.004 μM)over the family member Aurora B (IC50 = 0.172 μM)in cultured cells[2]. MLN8054 treatment results in G2/M accumulation and spindle defects and inhibits proliferation in multiple cultured human tumor cells lines (IC50 0.11-0.86μM) [2] . Growth of human tumor xenografts in nude mice was dramatically inhibited after oral administration of MLN8054 at well tolerated doses[2] .

References:

[1] MOL.CELL.BIOL. June 2007;27：4513–4525

[2] PNAS March 6, 2007;104：4106–4111

Chemical Information

Molecular Weight (WM): 476.86
Formula:

C25H15ClF2N4O2
Solubility(R.T.:25°C): DMSO 95mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

Cell Cycle >> Aurora Kinase >> Aurora Kinase Inhibitors

Recommended Screening Libraries

Related Inhibitors

Information  
VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.
  • 25mg
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ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively.
  • 5mg
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  • 10mg
  • $ 110
Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.
  • 5mg
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  • 10mg
  • $ 320
MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM.
  • 5mg
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  • 10mg
  • $ 210
AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.
  • 2mg
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  • 5mg
  • $ 170

Related Antibodies

Information  
Reactivity: 薛亚红

MLN8054 has been referenced in 3 publications.

Cdk activity couples epigenetic centromere inheritance to cell cycle progression.
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.

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Average Customer Review

(3 customer reviews)

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  • ;Professora Dra. Maria Gabriela Rodrigues(DBA/FCUL)
    MLN8054 purchased from Selleck


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  • ;Dev Cell, 2012, 22(1), 52-63
    MLN8054 purchased from Selleck


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  • ;Dr Zhang of Tianjin Medical University
    MLN8054 purchased from Selleck

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;Professora Dra. Maria Gabriela Rodrigues(DBA/FCUL)


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;Dev Cell, 2012, 22(1), 52-63

+ See All 3 Customer Reviews of MLN8054

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