MLN8054 is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity .
MLN8054 inhibits recombinant Aurora A kinase activity in vitro and is selective for Aurora A (IC50 = 0.004 μM)over the family member Aurora B (IC50 = 0.172 μM)in cultured cells. MLN8054 treatment results in G2/M accumulation and spindle defects and inhibits proliferation in multiple cultured human tumor cells lines (IC50 0.11-0.86μM)  . Growth of human tumor xenografts in nude mice was dramatically inhibited after oral administration of MLN8054 at well tolerated doses .
 MOL.CELL.BIOL. June 2007;27：4513–4525
 PNAS March 6, 2007;104：4106–4111
|Molecular Weight (WM):||476.86|
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;Professora Dra. Maria Gabriela Rodrigues(DBA/FCUL) MLN8054 purchased from Selleck
;Dev Cell, 2012, 22(1), 52-63 MLN8054 purchased from Selleck
;Dr Zhang of Tianjin Medical University MLN8054 purchased from Selleck
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