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MEK is a member of kinases in MAPK signal pathway which can activates p38 MAPK and JNK when MEK is ACTIVATED by TNF-alpha, GPCR and so on. MEK could be regulated by MEKKs or RAF. The Raf / MEK / ERK signal transduction is involved in cell growth, cell proliferation and cell survival. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1008 | AZD6244 (Selumetinib) | AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM. |
 (44)
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 (8)
|
| S1036 | PD0325901 | PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
(37)
|
(7)
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| S2673 | GSK1120212 (JTP-74057) | GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively. |
(2)
|
(2)
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| S1102 | U0126-EtOH | U0126-EtOH is a highly selective inhibitor of MEK1 and MEK2 with IC50 of 0.07 μM and 0.06 μM, respectively. |
(13)
|
(3)
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| S1177 | PD98059 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM. |
(8)
|
(4)
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| S1020 | CI-1040 (PD184352) | CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM. |
(22)
|
(9)
|
| S1531 | BIX 02189 | BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. |
(4)
|
(1)
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| S2617 | TAK-733 | TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM. |
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(2)
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| S2310 | Honokiol | Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway. |
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| S2134 | AZD8330 | AZD8330 (ARRY-424704) is a MEK 1/2 inhibitor with IC50 of 7 nM. |
(1)
|
(1)
|
| S1568 | PD318088 | PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. |
|
(1)
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