| Cat.No. |
Product Name |
Information |
Publication |
Customer Review |
| S1008 |
AZD6244 (Selumetinib) |
AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.
|
 (44)
|
 (8)
|
| S1036 |
PD0325901 |
PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
|
(37)
|
(7)
|
| S2673 |
GSK1120212 (JTP-74057) |
GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.
|
(2)
|
(2)
|
| S1102 |
U0126-EtOH |
U0126-EtOH is a highly selective inhibitor of MEK1 and MEK2 with IC50 of 0.07 μM and 0.06 μM, respectively.
|
(13)
|
(3)
|
| S1177 |
PD98059 |
PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM.
|
(8)
|
(4)
|
| S1020 |
CI-1040 (PD184352) |
CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.
|
(22)
|
(9)
|
| S1531 |
BIX 02189 |
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
|
(4)
|
(1)
|
| S2617 |
TAK-733 |
TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM.
|
|
(2)
|
| S2310 |
Honokiol |
Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway.
|
|
|
| S2134 |
AZD8330 |
AZD8330 (ARRY-424704) is a MEK 1/2 inhibitor with IC50 of 7 nM.
|
(1)
|
(1)
|
| S1568 |
PD318088 |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.
|
|
(1)
|
| S1530 |
BIX 02188 |
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM.
|
(1)
|
|
| S1475 |
AS703026 (pimasertib) |
AS703026 is a highly selective and potent non-competitive inhibitor of MEK1/2 with IC50 of 5-11 nM.
|
|
(1)
|
| S1066 |
SL327 |
SL327 is a selective inhibitor for MEK1 and MEK2 with IC50 of 0.18 μM and 0.22 μM, respectively.
|
|
|
