Home >> Protein Tyrosine Kinase >> c-Kit >> c-Kit Inhibitors >> Masitinib (AB1010)

United States (Change Country)

Masitinib (AB1010)

Catalog No. S1064 1 Customer Review(s)

Masitinib (AB1010) Chemical Structure

Bio Information

Masitinib (AB1010) is a tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM for KIT tyrosine phosphorylation and the recombinant human wild-type KIT. It can enhance the antiproliferative effects of gemcitabine (GEM) in human pancreatic cancer cells. It potently inhibited human and murine KIT with activating mutations in the juxtamembrane domain. In vivo, masitinib (AB1010) blocked tumour growth in mice with subcutaneous grafts of Ba/F3 cells expressing a juxtamembrane KIT mutant. ^[1][2][3]

References:

[1] PLoS ONE September 2009;4:e7258

[2] Allergy 2009;64: 1194–1201

[3] Stem Cells 2005;23:16–43

Chemical Information

Molecular Weight (WM):	498.64
Formula:	C₂₈H₃₀N₆OS

Solubility(R.T.:25°C):	DMSO 100mg/mL
	Water <1mg/mL
	Ethanol 4mg/mL

Quality Control

View current batch:

Purity= 99.74% H-NMR HPLC Purity= 99.56% H-NMR HPLC Purity= 99.16% Purity= 99.77% H-NMR HPLC

Research Area

Protein Tyrosine Kinase >> c-Kit >> c-Kit Inhibitors

Recommended Screening Libraries

L1100 Inhibitor Library
A collection of 715 inhibitors
L1200 Kinase Inhibitor Library
A collection of 271 kinase inhibitors
L1300 FDA Approved Drug Library
A collection of 785 FDA approved drugs
L1400 Natural Product Library
A collection of 144 natural products
L1500 Chemotherapeutic Agent Library
A collection of 84 chemotherapeutic agents
L1700 Pharmacologically Active Chemical Library
A collection of 1463 bioactive compounds
L1800 Tyrosine Kinase Inhibitor Library
A collection of 117 tyrosine kinase inhibitors

Related Inhibitors

Product Name	Information

Linifanib (ABT-869)

Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

5mg
$ 120

10mg
$ 210

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

50mg
$ 70

100mg
$ 120

BIBF1120 (Vargatef)

BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

5mg
$ 120

10mg
$ 210

Dovitinib (TKI-258)

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

10mg
$ 170

25mg
$ 270

Dasatinib (BMS-354825)

Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.5 nM and 79 nM, respectively.

25mg
$ 147

100mg
$ 370

Related Antibodies

Product Name	Information

Reactivity: 薛亚红

Your Recent History

Keywords:buy Masitinib (AB1010) | Masitinib (AB1010) supplier | purchase Masitinib (AB1010) | Masitinib (AB1010) cost | Masitinib (AB1010) manufacturer | order Masitinib (AB1010) | Masitinib (AB1010) distributor