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As a member of the kinesin superfamily of microtubule-basedmotors, Kinesin spindle protein (KSP) not only plays an important role in centrosome separation, but mediates the assembly and maintenance of bipolar spindle. Kinesins are a large superfamily of motor proteins that participate in various biological phenomena including mitosis and intracellular transport of vesicles and organelles. As targeting KSP provides a novel route for the manipulation of the cell cycle, KSP inhibitors can be used for cancer treatment because cell will stay in mitosis without the function of KSP.
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S2731 | AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM. |
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| S1452 | Ispinesib (SB-715992) | Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM. |
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| S2182 | SB 743921 | SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively. |
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| S2737 | ARRY-520 | ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro. |
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