As a member of the kinesin superfamily of microtubule-basedmotors, Kinesin spindle protein (KSP) not only plays an important role in centrosome separation, but mediates the assembly and maintenance of bipolar spindle. Kinesins are a large superfamily of motor proteins that participate in various biological phenomena including mitosis and intracellular transport of vesicles and organelles. As targeting KSP provides a novel route for the manipulation of the cell cycle, KSP inhibitors can be used for cancer treatment because cell will stay in mitosis without the function of KSP.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S1452||Ispinesib (SB-715992)||Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.|
|S2182||SB743921||SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively.|
|S2731||AZ 3146||AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.|
|S7090||GSK923295||GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. Phase 1.|