JNK is an important target which plays a crucial role in MAPK pathway, apoptosis and cell survival. JNK Regulates AP-1 Transcription Activity by phosphorylating c-Jun. Jnk, with p38 MAPK, belongs to MAPK pathway. Jnk is activated by MKK4 and MKK7.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S1460||SP600125||SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively.||(5)||(1)|
|S4901||JNK-IN-8||JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively.|