Retroviral integration is promoted by the viral integrase (IN) enzyme, which enters the cell as a component of the virion particle. Integrase enables retrovirus genetic material to be integrated into the host chromosome. It is essential to retrovirus replication. Integrase catalyzes two spatially and temporally distinct reactions within the context of the preintegration complex (PIC), a large structure derived from the virus core. The integrase inhibitors provide a novel target for antiretroviral therapy.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S2667||Dolutegravir (GSK1349572)||S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM.|
|S1366||BMS-707035||BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM.|
|S2765||MK-2048||MK-2048 is an potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.|