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The insulin-like growth factor (IGF-1 receptor), is a kind of tyrosine kinase receptors activated by IGF-1 is a transmembrane receptor consisting of two alpha-subunits and two transmembrane beta-subunits that are linked by disulfide bonds. The activation of IGF-1 receptors in turn leads to activation of distinct signaling pathways through Grb2, including the phosphatidylinositol 3-kinase (PI3K), Akt pathway and the Ras, Raf, mitogen-activated protein kinase (MAPK) pathway, leading to increasing in proliferation and decreased apoptosis. IGF-1 receptor is implicated in tumor and it is also an attractive target for cancer therapy.
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S1091 | Linsitinib (OSI-906) | OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively. |
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| S1093 | GSK1904529A | GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively. |
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| S1088 | NVP-ADW742 | NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM. |
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| S1034 | NVP-AEW541 | NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM. |
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| S2703 | GSK1838705A | GSK1838705A is a potent inhibitor of IGF-1R, IR and ALK with IC50 of 2.0 nM, 1.6 nM and 0.5 nM, respectively |
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| S1012 | BMS-536924 | BMS-536924 is an ATP-competitive IGF-1R and IR inhibitor with IC50 of 100 nM and 73 nM, respectively. |
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| S1124 | BMS-754807 | BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively. |
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| S7078 | Picropodophyllotoxin (Picropodophyllin, AXL1717) | AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM. |
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| S8003 | PQ 401 | PQ 401 is an IGF-1R inhibitor with IC50 of <1 μM. |
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| S1234 | AG-1024 | AG-1024 (Tyrphostin) is a specific IGF-1R and IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively. |
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