- |
My Account- |
Conformational maturation of targets in signal transductions is related to Heat shock protein 90 (Hsp90). Hsp90 keeps these unstable signalling proteins, including HER-2/ErbB2, Akt, Raf-1, Bcr-Abl and mutated p53, poised for activation until they are stabilized by conformational changes associated with signal transduction. HSP90 is also related to cell cycle because HSP90 can regulator the cell cycle regulator proteins such as CDK1.Inhibition of HSP90 can block cancer related pathways such as EGF-R and Her-2, Flt3, PI3K/PDK1/AKT, Ras, MEK, ERK, the Wnt/β-catenin pathway, and JAK-STAT pathway.
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1141 | 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. |
 (7)
|
 (1)
|
| S1069 | AUY922 (NVP-AUY922) | NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively. |
(3)
|
(1)
|
| S1052 | Elesclomol | Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells.. |
|
|
| S1159 | Ganetespib (STA-9090) | Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells. |
|
|
| S1142 | 17-DMAG HCl (Alvespimycin) | 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM. |
(3)
|
|
| S2713 | Geldanamycin | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM. |
|
|
| S1163 | AT13387 | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells. |
|
|
| S2685 | KW-2478 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
|
|
| S2639 | SNX-2112 | SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, respectively. |
|
|
| S2656 | PF-04929113 (SNX-5422) | PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and also inhibits Her-2 degradation with IC50 of 37 nM. |
|
|
| S1498 | NVP-BEP800 | NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
(2)
|
(2)
|
