Hypoxia-inducible factor (HIF) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.HIF-1α protein synthesis is regulated by activation of the phosphatidylinositol 3-kinase (PI3K) and ERK mitogen-activated protein kinase (MAPK) pathways. Then AKT, mTOR and p70 S6 kinase (S6K) are phosphorylated resulting in the inhibition of cap-dependent mRNA translation through binding of 4E-BP1 to eIF-4E. The effect of growth-factor signalling is an increase in the rate at which a subset of mRNAs within the cell (including HIF-1α mRNA) is translated into protein.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S1007||FG-4592||FG-4592 is an HIF α prolyl hydroxylase inhibitor.|
|S1233||2-Methoxyestradiol||2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.|
|S2919||IOX2||IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.|