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Hedgehog signaling pathway is an essential signaling pathway in embryonic development. Hedgehog signaling pathway also plays a critical role in human cancer. The signaling cascade of this pathway is initiated by binding of a Hh ligand to its membrane receptor PTCH which inhibits Smoothened (SMO) in the absence of Hh. After binding of a Hh ligand, the repression of SMO by PTCH1 is lifted. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1146 | Cyclopamine | Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM. |
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| S2157 | LY2940680 | LY2940680 binds to the Smo receptor and potently inhibits Hh signaling. |
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