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United States (Change Country)GSK1059615 Chemical Structure
GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kα (0.4 nM) and PI3Kβ (0.6 nM) and shows low nanomolar activity towards γ(5 nM),δ(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1]
[1] Informa healthcare September 2009;1265-1277
| Molecular Weight (WM): | 333.36 |
|---|---|
| Formula: | C18H11N3O2S |
| Solubility(R.T.:25°C): | DMSO 2mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL |
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;Antonino Maria Spartà from University of Bologna GSK1059615 purchased from Selleck
;Saraswati Sukumar of Johns Hopkins University School of Medicine GSK1059615 purchased from Selleck
;Dr Zhang of Tianjin Medical University GSK1059615 purchased from Selleck
;Dr. Yong-Weon Yi from Georgetown University Medical Center GSK1059615 purchased from Selleck
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