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Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase encoded by two isoforms (GSK-3α and GSK-3β) in all mammalian cells. GSK-3 could phosphorylate its target substrate on serine or threonine sites. Due to the involvement in numerous of signaling pathways, GSK-3 has been confirm to be important for the control of physiological functions and associate with many serious diseases. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S2924 | CHIR-99021 (CT99021) HCl | CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. |
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| S1263 | CHIR-99021 (CT99021) | CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. |
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| S2745 | CHIR-98014 | CHIR-98014 is a potent and selective GSK-3 inhibitor for GSK-3ɑ and GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively. |
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| S1075 | SB 216763 | SB 216763 is a potent and selective GSK-3α inhibitor with IC50 of 34.3 nM. |
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| S2823 | Tideglusib | Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM. |
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| S1590 | TWS119 | TWS119 is a GSK-3β inhibitor with IC50 of 30 nM. |
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| S2729 | SB 415286 | SB 415286 is a potent GSK3α and GSK3β inhibitor with IC50 of 78 nM and ~78 nM, respectively. |
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| S7063 | LY2090314 | LY2090314 is a potent GSK-3 inhibitor for GSK-3α and GSK-3β with IC50 of 1.5 nM and 0.9 nM, respectively. |
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| S2926 | TDZD-8 | TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM. |
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