GPR119, a orphan receptor, couples to Gs so that GPR119 can upregulate the intracellular cAMP obviously when GPR119 is expressed in high level.ATP-sensitive K+ and voltage-dependent Ca2+ channels are also involved in GPR119-mediated responses. GPR119 is involved in glucose-stimulated insulin secretion (GSIS), and GPR119 is also a beta-Cell-Specific GPCR and GPR119 is expressed highly in pancreatic islets and pancreatic β-cells so that researchers treat GPR119 as a potential target for drug development against type 2 diabetes.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S2637||TAK-875||TAK-875 is a selective GPR40 agonist with EC50 of 14 nM.|
|S8014||GW9508||GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32.|
|S2149||GSK1292263||GSK-1292263 is a novel GPR119 agonist.|