Estrogens receptors, steroid hormones, play a key role in many cell processes such as cell growth and cell differentiation. A number of cellular signaling pathways influence the ER-dependent gene expression modulating ER conformational changes or co-regulators recruitment. ER alpha not only can be activated by EGF, but can be activated by other growth factors including insulin, insulin-like growth factor-1 (IGF-1) and TGF-beta. In addition, heregulin, interleukin-2, and dopamine can also modulate ER activity. The phosphorylation of co-activators (SRC-1 and SRC-2) by MAPK pathway results in a general reduction in ER alpha transcriptional activity.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S1598||LY500307 (Erteberel)||LY500307 (SERBA-1) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM.|
|S2473||Hexestrol(Bibenzyl)||Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.|
|S2450||Equol||Equol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines.|
|S2832||Epiandrosterone (3β-androsterone)||Epiandrosterone (3β-androsterone) is a steroid hormone with weak androgenic activity which acts as a L-type Ca2+ channel antagonist.|