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EGFR is a trans-membrane receptor belonging to the erbB/HER-family of RTK. EGFR exists on the cell surface and can be activated by EGF and TGF-alpha. Many important signaling cascades, like MAPK, Akt, and JNK pathways, could be the downstream of EGFR. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
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| S1011 | Afatinib (BIBW2992) | BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. |
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| S1143 | AG-490 | AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively. |
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| S1167 | CP-724714 | CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM. |
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| S2727 | Dacomitinib (PF299804,PF-00299804) | PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively. |
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| S2728 | AG-1478 (Tyrphostin AG-1478) | AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM. |
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| S1019 | CI-1033 (Canertinib) | CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively. |
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| S1194 | CUDC-101 | CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively. |
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| S7039 | PD168393 |
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| S4911 | BMS-690514 |
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| S8009 | AG 18 (Tyrphostin 23) | AG 18 inhibits EGFR with IC50 of 35 μM. |
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| S2867 | WHI-P154 | WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM. |
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