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E7080 (Lenvatinib)

Catalog No. S1164 Product Citations1 Product Citation(s)
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$ 70 Yes
$ 150 Yes
$ 270 Yes
$ 770 Yes
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E7080 (Lenvatinib) Chemical Structure

Bio Information

E7080 (Lenvatinib) is the most potent dual inhibitor of VEGF-R3 tyrosine kinase (IC50=5.2 nM) as well as VEGF-R2 tyrosine kinase (IC50=4.0 nM) among those small-molecule inhibitors of VEGF-R kinases, such as sunitinib, sorafenib, and CEP-7055. It has been evaluated in vitro (pre-clinical) for anti-cancer effects. E7080 (Lenvatinib) suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of angiogenesis and lymphangiogenesis. [2,3]
It has had promising results from a phase I clinical trial in 2006 and is being tested in several Phase I and II trials as of October 2009, for example against hepatocellular carcinoma and non-small cell lung carcinoma. [1]

References:

[1] Clin Cancer Res 2009;15:7229-7237

[2] Clin Cancer Res 2008;14:5459-5465

[3] Int. J. Cancer 2008;122:664–671

Chemical Information

Molecular Weight (WM): 426.85
Formula:

C21H19ClN4O4
Solubility(R.T.:25°C): DMSO 40mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Research Area

Protein Tyrosine Kinase >> VEGFR >> VEGFR Inhibitors

Recommended Screening Libraries

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Information  
Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.
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Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
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BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
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Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.
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Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.
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Related Antibodies

Information  
Reactivity: 薛亚红

E7080 (Lenvatinib) has been referenced in 1 publications.

Anti-tumor Effects of Vascular Endothelial Growth Factor Receptor-3 Inhibitor on Oral Cancer Cells.

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