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CDKs (Cyclin-dependent kinases), a small heteromeric serine/threonine kinases with 34-40kDa, plays a key role in regulating cell cycle progression and transcriptional regulation. A CDK has to bind to a cyclin, a family of proteins that control the progression of cells, to gain its kinase activity.
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1116 | PD 0332991 (Palbociclib) HCl | PD 0332991 is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively. |
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| S2768 | Dinaciclib (SCH727965) | Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
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| S1524 | AT7519 | AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively. |
(2)
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(1)
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| S2679 | Flavopiridol (Alvocidib) HCl | Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM. |
(2)
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(1)
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| S1153 | Roscovitine (Seliciclib, CYC202) | Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively. |
(3)
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(3)
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| S1145 | SNS-032 (BMS-387032) | SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively. |
(1)
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(2)
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| S1249 | JNJ-7706621 | JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively. |
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(2)
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| S8058 | P276-00 | p276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. |
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| S7047 | BAY 1000394 | BAY 1000394 is an orally bioavailable CDK inhibitor. |
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| S1579 | PD 0332991 (Palbociclib) Isethionate | PD 0332991 (Palbociclib) Isethionate is the isethionate of PD 0332991, a highly specific inhibitor of CDK4 and CDK6 with IC50 of 11 nM and 16 nM, respectively. |
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| S2014 | BMS-265246 | BMS265246 is a potent and selective CDK inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively. |
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