As a member of the cannabinoid receptor family, CB2 receptors (Cannabinoid receptor 2), a G protein-coupled receptor, can modulate adenylyl cyclase and MAP kinase activity, through their ability to couple to Gi/o proteins. CB2 receptor stimulation is believed not to modulate ion channel function.Cannabinoids not only can bid to CB2 receptor, but also can modulate the activity of other receptor types including Opioid receptors, NMDA receptor, and nAChRs. Cannabinoids activate p42/p44 MAP kinase in CHO cells and HL-60 cells expressing the CB2 receptor. Cannabinoids were also shown to induce the expression of krox-24 through a PKC-dependent activation of MAP kinase.
|Cat.No.||Product Name||Information||Publication||Customer Review|
|S8012||CP-945598 HCl||CP-945598 HCl is a potent and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM.|
|S1534||Org 27569||Org 27569 is an allosteric modulator of CB1 cannabinoid receptor.|
|S1544||AM1241||AM-1241 is a selective CB2 agonist with Ki of 3.4 nM.|
|S2778||GW842166X||GW842166X is a potent and highly selective agonist of CB2 receptor.|
|S2854||BML-190||BML-190 is a selective CB2 inverse agonist with Ki of 435 nM.|
|S2819||AM251||AM251 is a cannabinoid 1 receptor antagonist with IC50 of 8.9 μM.|